Infection of capuchin monkeys (Cebus albifrons) with Herpesvirus saimiri.
J Natl Cancer Inst, 1975/3;54(3):673-7.
Rabin H, Pearson GR, Wallen WC, Neubauer RH, Cicmanec JL, Orr TW
PMID: 164564
Impact factor: 11.816
Abstract
Herpesvirus saimiri (HVS) induced persistent, clinically inapparent infections of long-term duration in capuchin monkeys (Cebus albifrons). The infections were characterized by development of antibody to HVS-associated antigens and recovery of low levels of virus-genome-carrying lymphocytes in the peripheral blood. Peripheral lymphocyte counts remained in low-normal to normal ranges and no physical signs of lymphoma were evident. Prednisolone treatment caused immunosuppression in one monkey; this was accompanied by a progressive loss of humoral antibody to HVS-associated antigens, but neoplastic disease did not develop.
MeSH terms
Animals; Antibodies, Viral; Haplorhini; Herpesviridae; Herpesviridae Infections; Herpesvirus 2, Saimiriine; Immunity; Immunity, Cellular; Leukocyte Count; Lymphocyte Activation; Lymphocytes; Mitogens; Prednisolone; Viral Plaque Assay
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