Primary tissue culture of human wart-derived epidermal cells (keratinocytes).
J Natl Cancer Inst, 1975/3;54(3):563-9.
Niimura M, Pass F, Wooley R, Soutor CA
PMID: 164558
Impact factor: 11.816
Abstract
The formation of human skin warts may depend on transformation by human papilloma virus or result from a productive virus infection. To explore this problem, methods were developed for the primary tissue culture of epidermal cells (keratinocytes) derived from wart tissues and normal skin. Wart-derived keratinocytes continued to proliferate for periods exceeding 3 months, but the patterns of cell growth were identical to normal keratinocytes. Electron microscopic and immunohistologic examination of wart-derived cultures did not evidence virion assembly.
MeSH terms
Animals; Antigens, Viral; Biopsy; Cell Division; Culture Techniques; Humans; Papillomaviridae; Rabbits; Virus Replication; Warts
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