Selection of a variant lymphoma cell deficient in adenylate cyclase.
Science, 1975/2/28;187(4178):750-2.
Bourne HR, Coffino P, Tomkins GM
PMID: 163487
Impact factor: 63.714
Abstract
Isoproterenol, a stimulator of adenylate cyclase, was used to select a stable variant clone of mouse lymphosarcoma cells deficient in the enzyme. The inability of four different stimulators to activate cyclic adenosine monophosphate synthesis in the variant, in contrast to its wild-type parent, implies that in normal cells one type of adenylate cyclase molecular can respond to different activators.
MeSH terms
Adenylyl Cyclases; Animals; Bucladesine; Clone Cells; Cyclic AMP; Enzyme Activation; Genetic Variation; Isoproterenol; Lymphoma, Non-Hodgkin; Mice; Neoplasms, Experimental; Phenotype; Prostaglandins; Stimulation, Chemical; Toxins, Biological; Vibrio cholerae
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