Rheumatoid synovial lymphocytes lack concanavalin-A-activated suppressor cell activity.
Scand J Immunol, 1979;10(5):479-86.
Chattopadhyay C, Chattopadhyay H, Natvig JB, Mellbye OJ
PMID: 161817
Impact factor: 3.889
Abstract
Synovial lymphocytes eluted by enzyme treatment from eleven patients with rheumatoid arthritis (RA) were investigated for the presence of concanavalin A (Con A)-activated suppressor cell activity as compared with that of peripheral blood lymphocytes of twenty normal donors. In addition, two patients with psoriatic arthritis and juvenile rheumatoid arthritis (JRA) were also investigated. Synovial lymphocytes from the eleven RA patients showed a mean augmentation of 28 +/- 13.30, and thus clearly lacked suppressor activity, whereas the mean suppression in the lymphocytes from the twenty normal donors was 13 +/- 14.40. Synovial lymphocytes from one patient with JRA and one with psoriatic arthritis showed a normal suppressor activity.
MeSH terms
Arthritis, Juvenile; Arthritis, Rheumatoid; Concanavalin A; Humans; Lymphocyte Activation; Lymphocytes; Synovial Membrane; T-Lymphocytes, Regulatory
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