[Demonstration of the myotoxic effect of theophylline on the isolated kidney glomerulus of the rat].
C R Seances Soc Biol Fil, 1979;173(5):904-9.
Cambar J, Saurel J, Canellas J
PMID: 161186
Abstract
After confirmation of the intense and very fast myorelaxant effect of theophylline on isolated glomeruli, xanthic reagent myotoxic effects are shown during more or less long contacts with these glomerular suspensions. We studied isolated glomeruli diameter evolution according to reagent dose (0,25 to 10 mg/ml) and its contact length (1, 5, 10 minutes). If the diameter remains practically constant during all the period for the lowest doses, it begins to decrease after the 5th minute for higher (1 and 2,5 mg/ml) and cracks up in the first minutes for the biggest ones (5 and 10 mg/ml). Pharmacologic and toxic actions are discussed ; hypothesis of a toxic effect at smooth muscular cells level is proposed.
MeSH terms
Animals; In Vitro Techniques; Kidney Glomerulus; Male; Muscle, Smooth; Rats; Theophylline; Time Factors
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