[Recent results in the field of vinblastine group antitumour alkaloids. Biochemical studies].
C R Seances Soc Biol Fil, 1979;173(2):414-24.
PMID: 159763
Abstract
Studies on the interaction between vinblastine-like alkaloids and their receptor, i.e. tubulin, are reported. They shed some light on the structure-activity relationships in this medicinally important series: the configuration at C14' and C16', as well as the presence of the methoxycarbonyl group on C16' seem to play an essential role in the determination of biological activity. A new analogue, detected by its specific behaviour with tubulin, was found, in vivo, to be as active and less toxic than vinblastine.
MeSH terms
Animals; Chemical Phenomena; Chemistry; Molecular Conformation; Polymers; Protein Binding; Structure-Activity Relationship; Tubulin; Vinblastine
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