Additional pharmacological aspects of orgotein, a metalloprotein with superoxide-dismutase activity.
Arzneimittelforschung, 1979;29(5):781-5.
Borrelli F, Serafini C, Mattalia G, Caprino L
PMID: 159058
Abstract
Orgotein is a copper- and zinc-containing protein with superoxide-dismutase activity which can be isolated from bovine liver and erythrocytes. The effects of this drug on adjuvant -induced arthritis in rats, and particularly on the changes in erythrocytes sedimentation rates and plasma fibrinogen levels induced by this experimental infection, were studied. Orgotein was also assayed on nystatin-induced paw edema, passive cutaneous anaphylaxis and Arthus reaction, in rats. Finally, studies on platelet aggregation and the prostaglandin system were conducted. Given at doses of 2.5 and 5 mg/kg i.p. for 14 days to arthritic rats, orgotein normalized the serum changes, inhibited the foot swelling and improved the performance time on the rotating bar. The drug reduced, after a single dose, the nystatin-induced edema, whilst it showed no effects on the immunological inflammations, platelet aggregation and prostaglandin system. The probable mechanism of action is discussed.
MeSH terms
Animals; Arthritis, Experimental; Arthus Reaction; Chemical Phenomena; Chemistry, Physical; Edema; Epoprostenol; Erythrocytes; In Vitro Techniques; Male; Metalloproteins; Platelet Aggregation; Prostaglandins A; Rats; Superoxide Dismutase
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