Transplantation-induced immune complex kidney disease in rats with unilateral manifestation in the allografted kidney.
Lab Invest, 1979/10;41(4):321-33.
Thoenes GH, Pielsticker K, Schubert G
PMID: 158673
Impact factor: 5.502
Abstract
Kidney transplantation between major histocompatibility system-identical rat strains LEW.1N (donor) and BN (recipient) is regularly followed by serious immune complex (membranous) glomerulonephritis. The disease localizes in the transplant only and spares the recipient's own contralateral kidney. The recipients develop both circulating immune complexes, as well as circulating antibodies against an allogeneic, tubular epithelial antigen of the donor. Antibodies eluted from the diseased kidneys display the same specificity. The transplant disease, therefore, is not autoimmune glomerulonephritis but an alloimmune, organ-specific illness unrelated to the usual histocompatibility system.
MeSH terms
Animals; Antigen-Antibody Complex; Glomerulonephritis; Immune Complex Diseases; Isoantibodies; Kidney; Kidney Transplantation; Organ Specificity; Rats; Rats, Inbred BN; Rats, Inbred Lew; Transplantation Immunology
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