[Combination of chemotherapy and radiotherapy. II. Differential effect on the medullary syndrome of irradiation combined with the drug administered in fractional doses and at various times].
C R Seances Soc Biol Fil, 1979;173(1):161-4.
Maisin H, Anckaert MA, Van Evercoren A, De Coster BM
PMID: 158411
Abstract
We have studied the effect of 5-Fu in fractional doses on the medullar syndrome after a single whole body cobalt irradiation in mice. The bone marrow is not sensitive to the fractionation of 5-Fu and it is the single dose of 5-Fu injected 72 hours after the irradiation which is the most effective.
MeSH terms
Animals; Bone Marrow Diseases; Drug Administration Schedule; Female; Fluorouracil; Lethal Dose 50; Mice; Mice, Inbred BALB C; Time Factors
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