Phagocytosis of chromium during patellar osteoarthritic remodelling associated with a knee prosthesis.
Virchows Arch A Pathol Anat Histol, 1979/5/14;382(1):119-26.
PMID: 157595
Abstract
The report is of an anatomico-pathological and electron probe microanalyzer study of a patella with osteoarthritic remodelling, that had been in contact with a cast cobalt-chromium-molybdenum prosthesis for two years and seven months. Abrasion of the metal resulted in preferential phagocytosis of chromium, principally in the wall of an osteoarthritis cyst. This observation indicates that a substance administered by intra-articular pathway for the treatment of osteoarthritis can become phagocytosed, and quite deeply, in the remodelled bone.
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