[Effects of chlorpromazine on hypertension by desinhibition in dogs: comparison of intravenous and intracisternal administration].
C R Seances Soc Biol Fil, 1978;172(5):978-82.
Montastruc JL, Moreno-Gonzalez A, Cotonat J
PMID: 157215
Abstract
The tensional effects of intravenous and intracisternal chlorpromazine were studied in neurogenic hypertensive dogs by desinhibition and bilateral vagotomy. Intravenous (2-5 mg/kg) chlorpromazine corrected instantaneously the rise in blood pressure after desinhibition, but was inactive on tachycardia. Intracisternal (0.5-2 mg/kg) chlorpromazine was always inactive in the desinhibited dog. These results exclude an intervention from baro -- or chemo -- receptors and central sympathetic structures (alpha adrenergic or dopaminergic receptors). They show that the hypotensive effect of chlorpromazine is a peripheral mechanism.
MeSH terms
Animals; Blood Pressure; Blood-Brain Barrier; Brain; Chlorpromazine; Dogs; Female; Heart Rate; Hypertension; Injections, Intravenous; Male; Vagotomy
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