[Immunological examination of lymphocytes in patients with sarcoidosis and bronchial asthma (author's transl)].
Prax Klin Pneumol, 1979/4;33 Suppl 1:366-70.
Thiel A, Thiel E, Baur X, Scholz S, Grosse-Wilde H
PMID: 156917
Abstract
Blood lymphocytes of 31 patients with bronchial asthma and of 20 patients with sarcoidosis were isolated and investigated for the following surface markers: E-receptors (E-rosettes, a T cell characteristic), Fc-receptors (EA-rosette assay), C3-receptors (EAC-rosette assay), surface immunoglobulins (immuno-fluorescence technique). In addition, the reactivity against allogeneic lymphocytes was tested in mixed lymphocyte culture (MLC). MLC properties were defined by homozygous reference cells (so-called LD-typing). HLA-typing was performed simultaneously. The results, so far, indicate in both disease groups a series of remarkable alterations of the lymphatic subpopulations. A marked diminution of circulating T lymphocytes was encountered in some cases. The immunological results are discussed in relation to pathogenetic aspects of the diseases.
MeSH terms
Asthma; Binding Sites; Complement C3; Histocompatibility Testing; Humans; Immunoglobulin Fc Fragments; Lymphocyte Culture Test, Mixed; Lymphocytes; Receptors, Antigen, B-Cell; Rosette Formation; Sarcoidosis
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