Low responsiveness of synovial and peripheral blood lymphocytes stimulated by either PHA-P or CON-A in patients with chronic rheumatoid arthritis.
Acta Med Okayama, 1978/12;32(6):441-7.
Yamana S, Matsueda H, Ezawa H, Miyake S, Katsuyama S, Ofuji T
PMID: 154829
Impact factor: 0.744
Abstract
Lymphocytes were highly purified from synovial fluid and peripheral blood of 10 rheumatoid arthritis patients and assessed for responsiveness to PHA-P and Con-A. In all cases, both synovial and blood lymphocytes showed a marked reduction in response to these mitogens compared with normal blood lymphocytes. The factors responsible for this low T cell responsiveness are discussed.
MeSH terms
Arthritis, Rheumatoid; Chronic Disease; Concanavalin A; Humans; Lymphocyte Activation; Phytohemagglutinins; Synovial Fluid
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