Is the diabetogenic effect of streptozotocin in part thymus-dependent?
Acta Pathol Microbiol Scand C, 1978/2;86(1):23-7.
PMID: 152048
Abstract
Following a single injection of 200 mg streptozotocin/kg BW, 25 out of 25 normal mice became diabetic, whereas 12 ( = 20%) out of 50 athymic nude mice did not develop diabetes. In a multiple dosage experiment, where the same total dose was given over a 5 days period, 14 normal and 15 athymic nude mice all became diabetic, but nude mice had significantly lower blood glucose values. These results support our previous suggestion that a thymus dependent immune reaction is, in part, responsible for the diabetogenic effect of streptozotocin.
MeSH terms
Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Immunity, Cellular; Injections, Intraperitoneal; Islets of Langerhans; Male; Mice; Mice, Inbred Strains; Mice, Nude; Streptozocin; Thymus Gland
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