[On the reduction of free fatty acids in skin surface lipids as a criterium for the therapeutic efficacy of antimicrobial acne drugs. Studies on film masks containing ethyl lactate and ethanol (author's transl)].
Arzneimittelforschung, 1977;27(11):2179-81.
PMID: 146497
Abstract
Thin-layer chromatographic investigations of the skin surface lipids have been performed on 10 healthy subjects before and after treatment with film masks containing 1% ethyl lactate and 50% ehtanol. From the results obtained it can be assumed that there is a reduction in the fraction of free fatty acids on the skin surface. Clinical studies with the same mask on 23 patients with acne vulgaris over a period of 3 weeks proved that this treatment led to a significant reduction in comedones and inflammatory acne efflorescences. No side effects whatsoever were obtained. This therapy, therefore presents a valuable element in the treatment of acne vulgaris. These investigations show also that a decrease in the free fatty acids of the skin surface lipids points to a favourable therapeutical effect on inflamed and not-inflamed efflorescens of acne vulgaris when testing antimicrobial agents.
MeSH terms
Acne Vulgaris; Adolescent; Adult; Anti-Infective Agents, Local; Ethanol; Fatty Acids, Nonesterified; Female; Humans; Lactates; Lipid Metabolism; Male; Skin
More resources
EndNote: Download