[Interaction of p-Dimethylaminoazobenzene with rat liver-chromatin and non-histones (author's transl)].
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol, 1978/1/26;91(1):55-61.
PMID: 146342
Abstract
The carcinogenic p-Dimethylaminoazobenzene and the non-carcinogenic p-aminoazobenzene were radioactive labelled and applicated to Whistar rats intraperitoneally. A very significant difference in binding tendencies for the two compounds and their metabolites was observed in rat liver tissues, rat liver nuclei and rat liver chromatin. Above all a specific binding affinity of the carcinogen to nuclear non-histone protein was found.
MeSH terms
Animals; Chromatin; Liver; Male; Nucleoproteins; Protein Binding; Rats; p-Aminoazobenzene; p-Dimethylaminoazobenzene
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