Effect of ouabain on sodium movement in cardiac cells.
Recent Adv Stud Cardiac Struct Metab, 1976/5/26-1976/5/29;11:401-5.
PMID: 145632
Abstract
A computer simulation indicates that intracellular sodium concentration within a space near the inner surface of sarcolemma fluctuates during a cycle of myocardial function. The sodium transient (a transient increase in sodium ion concentration associated with membrane excitation) is enhanced by the inhibition of (Na+, K+)-ATPase by ouabain, but an accumulation of myocardial sodium does not occur until the inhibition exceeds a critical point. The critical magnitude of sodium pump inhibition that causes a progressive sodium accumulation is dependent on the heart rate.
MeSH terms
Adenosine Triphosphatases; Animals; Biological Transport; Cell Membrane; Computers; Kinetics; Models, Biological; Myocardial Contraction; Myocardium; Ouabain; Sarcolemma; Sodium
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