[Study of the active calcium transport mechanisms in uterine smooth muscle].
Vopr Med Khim, 1976/3-1976/4;22(2):223-7.
Kurskiĭ MD, Fedorov AN, Iakovenko AP
PMID: 140526
Abstract
Calcium ions were shown to be actively accumulated in mitochondrial and microsomal fractions of uterine smooth muscle of rabbit and cattle. In presence of magnesium ions Ca2+ (10-6-10-4 M) activate microsomal ATPase from cattle uterus. The rate of formation and dissociation of the intermediate phosphorylated substance of Mg2+, Ca2+-ATPase was found to be lower in microsomes of smooth muscles than in sarcoplasmic reticulum of sceletal muscles. Serotonine (concentration 10-6 M) increased the dissociation of the intermediate phosphorylated substance from microsomes of uterine smooth muscle and decreased their capacity to bind Ca2+. At the same concentration serotonine inhibited the ATP-dependent accumulation of 45Ca by microsomes of uterine smooth muscle.
MeSH terms
Adenosine Triphosphatases; Animals; Biological Transport, Active; Calcium; Calcium Radioisotopes; Cattle; Female; Microsomes; Mitochondria, Muscle; Muscle, Smooth; Oxidative Phosphorylation; Rabbits; Sarcoplasmic Reticulum; Serotonin; Uterus
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