[Mechanism of action of some quinoline alkaloids on respiratory chain of mitochondria].
Biokhimiia, 1976/12;41(12):2220-8.
Akimenko VK, Kozlovskii AG, Medentsev AG, Golovchenko NP, Arinbasarov MU
PMID: 139172
Abstract
The mechanism of action of some quinoline alkaloids and their derivatives on respiratory chain of rat liver and Candida lipolytica yeast mitochondria was studied. The alkaloids were shown to inhibit electron transfer in the respiratory chain. The site of their action is localized between b and c cytochromes. Besides their ability to inhibit electron transfer in the respiratory chain, alkaloids are shown to be specific inhibitors of "exogenous" NADH-dehydrogenase of C. lipolytica yeast mitochondria. In addition to their inhibiting properties alkaloids can stimulate ATPase activity of mitochondria. O-alkylation of pseudane-IX permits to differentiate the inhibiting and uncoupling properties of this alkaloid.
MeSH terms
Adenosine Triphosphatases; Alkaloids; Animals; Candida; Cytochromes; Electron Transport; Enzyme Activation; Mitochondria; Mitochondria, Liver; NADH, NADPH Oxidoreductases; Quinolines; Rats; Uncoupling Agents
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