Why do tumor cells have a high aerobic glycolysis?
J Cell Physiol, 1976/12;89(4):697-700.
PMID: 137907
Impact factor: 6.513
Abstract
In Ehrlich ascites cells and several other tumors, the high aerobic glycolysis is maintained by generation of ADP and Pi by the plasma membrane Na+K+ ATPase. The high ATP activity is caused by a defective pump that operates at a low efficiency. Studies of the mechanism of action of the Na+K+ ATPase and other pump ATPases suggest several alternative mechanisms that might account for the decreased efficiency. The possibility of involvement of a proteolipid is under investigation.
MeSH terms
Adenosine Triphosphatases; Adenosine Triphosphate; Aerobiosis; Animals; Carcinoma, Ehrlich Tumor; Cell Membrane; Culture Techniques; Dinitrophenols; Glycolysis; Hydrolysis; Lactates; Ouabain; Potassium; Quercetin; Sodium
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