[General pharmacology and secretion inhibitory action of (8r)-3alpha-hydroxy-8-isopropyl-1alphaH,5alphaH-tropanium bromide-(+/-)-tropate (ipratropiumbromide) (author's transl)].
Arzneimittelforschung, 1976;26(5a):974-80.
Bauer R, Kuhn FJ, Stockhaus K, Wick H
PMID: 134727
Abstract
(8r)-3alpha-Hydroxy-8-isopropyl-1alphaH,5alphaH-tropaniumbromide-(+/-)-tropate (ipratropiumbromide, Sch 1000) is a quaternary tropic acid tropane ester with pronounced anticholinergic activities (inhibition of secretion and spasmolysis). The effect of the substance of all parasympathetically innervated organs ist 1.4 to 2 times stronger than that of atropine. As an inhibitor of the secretion of free hydrochloric acid in the stomach it proved to be 5 times more effective than atropine. Central activities were not observed. The duration of action of Sch 1000 exceeds that of atropine by far.
MeSH terms
Animals; Atropine Derivatives; Blood Pressure; Brain; Cats; Dogs; Ganglia, Autonomic; Gastric Juice; Guinea Pigs; Heart Rate; In Vitro Techniques; Intestinal Absorption; Ipratropium; Mice; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Oxotremorine; Parasympatholytics; Pupil; Rabbits; Rats; Salivation; Tremor
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