Synthesis of purine and pyrimidine substituted nitroxides.
Z Naturforsch C Biosci, 1976/1-1976/2;31(1-2):101-2.
Harcus R, Preston PN, Suffolk JS
PMID: 132036
Abstract
Reaction of 6-hydrazinopurine and 2-hydrazinopyrimidine with 2, 2, 6, 6-tetramethylpiperidone-1-oxyl gives 2, 2, 6, 6-tetramethylpiperidone-1-oxyl-(6-purinyl) hydrazone (3b) and 2, 2, 6, 6-tetramethylpiperidone-1-oxyl-(2-pyrimidinyl) hydrazone (4b) respectively. Compound 3b is inactive even at high dose levels against TLX/5 lymphoma and 3b and 4b are both inactive in tests using the L1210 leukaemia system.
MeSH terms
Animals; Antineoplastic Agents; Cyclic N-Oxides; Leukemia L1210; Lymphoma; Piperidines; Piperidones; Purines; Pyrimidines
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