Species differences in platelet aggregation induced by platelet-activating factor (PAF).
Methods Find Exp Clin Pharmacol, 1992/11;14(9):663-5.
Shinozaki K[1], Kawasaki T, Kambayashi J, Sakon M, Shiba E, Ou M, Mori T
Affiliations
PMID: 1294855
Abstract
Species differences in platelet aggregation induced by platelet-activating factor (PAF) were investigated by using the same procedure of platelet preparation and biological assay. Washed platelets of six different species (horses, dogs, rats, rabbits, sheep and guinea pigs) were prepared employing the same method and platelet aggregation was induced by C16-PAF. Horse platelets were most sensitive to PAF (8.0 x 10(-12) M) and rabbit platelets activated by 5.0 x 10(-11) M PAF were also sensitive enough to detect PAF in clinical samples.
MeSH terms
Animals; Dogs; Guinea Pigs; Horses; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Rabbits; Rats; Sheep; Species Specificity
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