Immunosuppression by embryonic liver cells.
Transplantation, 1975/12;20(6):480-4.
Globerson A, Zinkernagel RM, Umiel T
PMID: 128855
Impact factor: 5.385
Abstract
Liver cells from embryonic and newborn mice were found to interfere with mixed lymphocyte culture (MLC) reactions measuring either cytotoxicity by 51Cr release from target cells or 3H-thymidine incorporation. In both experimental systems a suppression was noted when the stimulator cells were syngeneic or unrelated to the liver donor. In addition, 18-day embryonic and neonatal liver cells were found to interfere with production of antibodies to alpha-dinitrophenyl-poly-L-lysine (alpha-DNP-PLL) in vitro. These findings conform with the hypothesis that embryonic cells can actively suppress immune reactions and thereby prevent a possible response to self.
MeSH terms
Aging; Animals; Animals, Newborn; Antibody Formation; Dinitrophenols; Female; Fetus; Immunosuppression Therapy; Liver; Lymph Nodes; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Polylysine; Pregnancy; Spleen
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