Serotonin content in the central nervous system of rats and cholinergic tremor.
Pol J Pharmacol Pharm, 1975/10;27(Suppl):167-72.
Oelszner W, Funk KF, Staib AH, Westermann KH
PMID: 128745
Abstract
Oxotremorine did not alter the level of 5-HT and 5-hydroxyindoleacetic acid in different brain regions. The content of 5-HT in the striatum was diminished by electrolytic lesions of the raphe system, by microinjection of the selective depletor 5,6-dihydroxytryptamine into the raphe system and inhibition of synthesis by pCPA or pCAM. The intensity of oxotremorine-induced tremor was reduced only in some experimental groups without clear-cut correlation to the decreased 5-HT levels. In pCPA-pretreated animals resoring of 5-HT concentration by intrastriatal microinjection of 5-HT and ip administration of 5-HT did not reestablish tremor intensity. There is no evidence that cholinergic tremor is triggered indirectly and depends upon an intact 5-HT system.
MeSH terms
Animals; Brain; Brain Chemistry; Female; Fenclonine; Hydroxyindoleacetic Acid; Oxotremorine; Parasympathetic Nervous System; Rats; Serotonin; Thalamic Nuclei; Tremor
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