Increased hemoglobin AIc in diabetic mice.
Diabetes, 1976/1;25(1):1-5.
Koenig RJ, Araujo DC, Cerami A
PMID: 128480
Impact factor: 9.337
Abstract
The minor hemoglobins AIa, AIb, and AIc were studied in mice with either genetic or chemically induced diabetes. Hemoglobin AIc was elevated approximately twofold in all the phenotypically diabetic mice studied (C57BL/KsJ-db/db, C57BL/KsJ-ob/ob, C57BL/6J-db/db, and alloxan- and streptozotocin-treated mice). Elevation of the hemoglobin AIc in C57BL/6J-db/db mice was of short duration, reflecting the transitory diabetes characteristic of these mice. The degree of increase of hemoglobin AIc levels was unrelated to severity of hyperglycemia, duration of diabetes, age of mouse, or body weight. It is not known what factor(s) dictates the steady-state concentration of hemoglobin AIc.
MeSH terms
Age Factors; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Experimental; Female; Hemoglobins; Male; Mice; Mice, Inbred C57BL; Mutation; Phenotype; Species Specificity; Streptozocin; Time Factors
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