The effects of glycosaminoglycans on surface-mediated interactions of lymphoid cells.
Folia Biol (Praha), 1975;21(2):87-94.
Viklický V, Pokorná Z, Pĕknicová J
PMID: 126179
Impact factor: 1.167
Abstract
The effect of chondroitin sulphate (CS) was studied in two cell surface-mediated interactions, the complement-independent contact reaction and antibody-induced capping of H-2 antigens. CS inhibited contact cytotoxicity when present in the reaction medium, but preincubation in CS of either killer cells or target cells had no effect. The capacity of CS-pretreated target cells to absorb H-2 antibodies was not reduced. However, a similar pretreatment resulted in an increased readiness to capping as induced by H-2 antibody followed by an anti-mouse immunoglobulin; in control cells time taken for the same percentage of caps to be formed was considerably longer than in CS-pretreated cells. A possible mechanism of this CS effect and the general biological role of glycosaminoglycans (particularly in immune interactions) is discussed.
MeSH terms
Animals; Antibody Formation; Chondroitin Sulfates; Complement System Proteins; Cytotoxicity Tests, Immunologic; Glycosaminoglycans; Histocompatibility Antigens; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred C57BL
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