The anti-inflammatory actions of tilorone hydrochloride.
Proc Soc Exp Biol Med, 1975/5;149(1):89-93.
Megel H, Raychaudhuri A, Shemano I, Beaver TH, Thomas LL
PMID: 124872
Abstract
Tilorone suppressed inflammation induced by immune (direct passive Arthus reaction) as well as by non-immune agents (carrageenam-induced paw edema and abscess formation), if the compound is given 24 hr prior to the proinflammatory agonists. The non-immune anti-inflammatory effect is independent of the adrenals. A surprising findings was that total serum hemolytic complement is markedly elevated 24 hr after a single dose of tilorone.
MeSH terms
Abscess; Administration, Oral; Adrenal Glands; Animals; Anti-Inflammatory Agents; Arthus Reaction; Carrageenan; Complement System Proteins; Edema; Female; Fluorenes; Hydrocortisone; Indomethacin; Phenylbutazone; Rats; Tilorone; Time Factors
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