Does gastrin (pentagastrin) act directly on the parietal cell in the isolated whole stomach of the mouse?
Pharmacology, 1979;19(6):315-22.
PMID: 121466
Impact factor: 3.429
Abstract
Acid secretory effect of pentagastrin and compound 48/80 was studied in the isolated whole stomach of the mouse. Acid secretory response to compound 48/80 was inhibited by cimetidine, indicating histamine involvement in this reaction. Acid secretion stimulated by pentagastrin was not diminished after pre-treatment with compound 48/80 suggesting that gastrin releases non-mast cell histamine. Secretory response to pentagastrin was reduced in Ca++-free serosal media but not to histamine and compound 48/80. A possible pathway of gastrin will be discussed.
MeSH terms
Amine Oxidase (Copper-Containing); Animals; Calcium; Cimetidine; Female; Gastric Juice; Histamine; Male; Mice; Pentagastrin; Stomach; p-Methoxy-N-methylphenethylamine
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