The pharmacology of diclofenac sodium (Voltarol).
Rheumatol Rehabil, 1979;Suppl 2:11-21.
Maier R, Menassé R, Riesterer L, Pericin C, Ruegg M, Ziel R
PMID: 119295
Abstract
Diclofenac is a potent anti-inflammatory and analgesic compound with good antipyretic and uricosuric properties. It is one of the most potent inhibitors of prostaglandin synthetase known. It shows a favourable therapeutic ratio considering its efficacy, and proved superior to the reference drugs in terms of gastro-intestinal tolerability. All metabolites are clearly less potent than the parent compound.
MeSH terms
Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Mice; Models, Biological; Phenylacetates; Rats; Uricosuric Agents
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