Differential tolerance to dietary amino acid-induced changes in aggressive behavior and locomotor activity in mice.
Psychopharmacology (Berl), 1979;66(3):301-8.
Thurmond JB, Lasley SM, Kramarcy NR, Brown JW
PMID: 119277
Impact factor: 4.415
Abstract
Male albino mice were maintained on a semisynthetic 12% casein protein diet for 2 weeks, then switched to diets modified by the addition of a 4% L-amino acid supplement (L-tyrosine, L-phenylalanine, and L-tryptophan) or 4% casein (control). Territorial=induced aggressive behavior increased following 1 week on the amino acid supplements, especially after tyrosine, but an apparent tolerance developed to these effects after 5 weeks on the amino acid supplements. Locomotor activity also increased following 1 week on the supplements, most notably after phenylalanine alone or in combination with tyrosine, and these effects tended to persist after 5 weeks on the supplements. Endogenous whole brain levels of dopamine, norepinephrine, serotonin, 5-hydroxyindoleacetic acid, tyrosine, phenylalanine, and tryptophan showed no tolerance to increased concentrations of brain catecholamines and indoleamines over the 5-week period, and no clear relation between the concentrations of these monoamines and the behavioral changes.
MeSH terms
Aggression; Amino Acids; Animals; Brain Chemistry; Catecholamines; Diet; Drug Tolerance; Humans; Male; Mice; Motor Activity; Time Factors
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