The dorsal noradrenergic bundle and varieties of passive avoidance.
Psychopharmacology (Berl), 1979/11;66(2):179-82.
PMID: 119260
Impact factor: 4.415
Abstract
Neither acquisition learning nor 24-h retention was significantly altered by 6-hydroxydopamine intracerebral injections which depleted forebrain noradrenaline (NA) to less than 5% of control values. The absence of passive avoidance impairment cannot be ascribed to functional recovery following the lesion (indicated by testing 24 h post-operation) and by using the F-344 strain of rat which does not show denervation supersensitivity as measured by NA-sensitive adenylate cyclase. Nonassociative freezing to electric footshock, changed by the injections, resulted in slower acquisition at a footshock level 4 mA, but not at 1 mA.
MeSH terms
Adenylyl Cyclases; Animals; Avoidance Learning; Electroshock; Escape Reaction; Male; Motor Activity; Neural Pathways; Norepinephrine; Rats; Rats, Inbred F344
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