Biochemical and morphologic studies on diabetic rats: effects of sucrose-enriched diet in rats with pancreatic islet transplants.
Proc Natl Acad Sci U S A, 1979/11;76(11):5905-9.
Eder HA, Novikoff PM, Novikoff AB, Yam A, Beyer M, Gidez LI
PMID: 118459
Impact factor: 12.779
Abstract
Isolated pancreatic islets were administered to Lewis rats with streptozotocin-induced diabetes. Then the rats were fed either a semisynthetic diet containing 60% (wt/wt) sucrose for 3 weeks or were continued on chow. Transplantation resulted in a decrease in serum glucose, an increase in serum insulin, and a marked decrease in serum triacylglycerol, particularly in the sucrose-fed diabetic rats. In these rats, in demarcated areas of hepatocytes surrounding portal vein termini, lipid was deposited in the cytosol and large lipoprotein particles engorged the Golgi apparatus, Golgi-derived secretory vacuoles, and GERL. This model permits observation of the effects of pancreatic islet hormones on lipogenesis by hepatocytes in situ.
MeSH terms
Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Fatty Liver; Insulin; Islets of Langerhans Transplantation; Lipid Metabolism; Liver; Male; Rats; Transplantation, Isogeneic; Triglycerides
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