[Studies on cellular protein synthesis in synovial fluid following intraarticular gold administration (author's transl)].
Arzneimittelforschung, 1978;28(12):2352-4.
Bröll H, Altmann H, Kocsis F, Eberl R
PMID: 115476
Abstract
Na-aurothiomalate was applied intraarticularly in the conentration range between 2 and 40 mg to joints of patients with rheumatoid arthritis. Between 2 and 20 mg a constant inhibition of 3H-aminoacids incorporation in proteins was observed. At a dosage of 40 mg of this gold salt a strong inhibition could be detected. In the low concentration range an additional degradation of structurally changed proteins could be the cause of the lower incorporation rate of 3H-aminoacids. From 40 mg on a real inhibition of protein synthesis seems to occur.
MeSH terms
Amino Acids; Arthritis, Rheumatoid; Gold Sodium Thiomalate; Humans; Protein Biosynthesis; Synovial Fluid; Time Factors
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