Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.
Proc Natl Acad Sci U S A, 1979/8;76(8):3774-8.
Siegel MI, McConnell RT, Cuatrecasas P
PMID: 115007
Impact factor: 12.779
Abstract
Aspirin, indomethacin, and sodium salicylate are anti-inflammatory, analgesic, and antipyretic. Whereas aspirin and indomethacin inhibit prostaglandin synthetase (cyclo-oxygenase; 8,11,14-eicosatrienoate, hydrogen-donor: oxygen oxidoreductase, EC 1.14.99.1), salicylate does not. However, all three drugs affect the metabolism of arachidonate via the lipoxygenase pathway by inhibiting the conversion of 12-hydroperoxy- to 12-hydroxy-5,8,10,14-eicosatetraenoic acid.
MeSH terms
Arachidonic Acids; Aspirin; Blood Platelets; Humans; Hydroxy Acids; Indomethacin; Lipoxygenase Inhibitors; Peroxidases; Salicylates; Thrombin
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