Demonstration of hepatitis B e antigen (HBeAg) in association with intact Dane particles.
J Gen Virol, 1979/5;43(2):423-7.
PMID: 113499
Impact factor: 5.141
Abstract
Mild detergent treatment (0.1% Sarkosyl-0.1% beta-mercaptoethanol) of Dane particle-rich fraction from human serum resulted in the release of core particles together with HBe antigen activity when examined by the reversed passive haemagglutination method. Furthermore, when the core particles isolated by the above procedure were exposed to stronger detergent (1% Sarkosyl-0.1% beta-mercaptoethanol), additional HBe antigen activity was released only from intact core particles with DNA polymerase activity and not from empty core particles.
MeSH terms
Carrier State; Centrifugation, Density Gradient; Hemagglutination Tests; Hepatitis B; Hepatitis B Antigens; Hepatitis B Core Antigens; Humans; Immunodiffusion; Surface-Active Agents
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