Transplantability of chemically induced skin tumors in syngeneic strains of mice, rats, and guinea pigs.
Exp Pathol (Jena), 1979;17(3):121-7.
PMID: 113243
Abstract
Syngeneic tumour transplants to inbred female animal strains were carried out with basaliomas, squamous cell carcinomas and fibrosarcomas of the skin, induced by DMBA (9,10-dimethyl-1,2-benzanthracene) in the mouse, rat and guinea pig. A completely successful transplantation of all tumors was only achieved in the group of fibrosarcomas of the rat when a myocardial suspension of a young rat was used as a "supporting agent". This may be a new immuno-biological aspect in tumor transplantation. In the other groups, five tumors developed in the host animals after a period of latency of 10 months or more. Therefore, it is discussed whether two of these tumors grown in the host rats should be considered spontaneous. In addition I have found no earlier reports in the literature with successful DMBA-induced epidermal tumors transplantations in homologous or syngeneic animal strains. Tumors were grafted on to altogether 100 animals.
MeSH terms
9,10-Dimethyl-1,2-benzanthracene; Animals; Fibrosarcoma; Guinea Pigs; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Skin Neoplasms; Species Specificity; Transplantation, Isogeneic
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