Extrapyramidal effects of neuroleptics.
J Neurol Neurosurg Psychiatry, 1976/9;39(9):866-9.
PMID: 11277
Impact factor: 13.654
Abstract
A study was conducted on 66 psychiatric inpatients who took major tranquilizers for periods of four to 16 years. The frequency of signs of Parkinsonism and the effects of orphenadrine on these were studied in a double-blind crossover method. Sixty-one per cent of the patients showed signs of Parkinsonism. Female patients and those with organic brain pathology more frequently exhibited Parkinsonism (although the difference was not statistically significant). No correlation was found between duration of treatment and extrapyramidal effects. Of the 40 patients who developed Parkinsonism, 25 responded favourably to orphenadrine, while six (15%) had more marked manifestations on orphenadrine than on placebo.
MeSH terms
Adult; Age Factors; Antipsychotic Agents; Clinical Trials as Topic; Dyskinesia, Drug-Induced; Extrapyramidal Tracts; Female; Humans; Male; Middle Aged; Orphenadrine; Parkinson Disease; Parkinson Disease, Secondary; Phenothiazines; Sex Factors; Time Factors; Tranquilizing Agents
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