Temperature dependence of ADH-induced water flow and intramembranous particle aggregates in toad bladder.

Science, 1979/8/31;205(4409):910-3.

Kachadorian WA, Muller J, Rudich SW, DiScala VA

PMID: 112678

Impact factor: 63.714

Abstract
Antidiuretic hormone (ADH)-induced luminal intramembranous particle aggregates and hormonally stimulated water flow in toad urinary bladder are reduced simultaneously with a reduction in temperature. When water movement is factored by the aggregation response, the apparent activation energy for this process decreases from 12.1 +/- 1.6 to 3.0 +/- 2.3 kilocalories per mole. The data are consistent with the view that the particle aggregates contain sites for transmembrane water movement and that these sites behave as pores.
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