[Teratogenic damages of the male genital organs].
Fortschr Med, 1976/10/21;94(30):1673-5.
PMID: 11158
Abstract
1. Malformations and functional disturbances of the male genitalia may be caused by teratogens. 2. A short review of the prenatal development points out the possible sites of action. 3. In animals some distinct teratogens produce typical malformation syndromo spermatogenetic cells. Cyproteronacetat, an antiandrogen, suppresses the development of the accessoric genital organs and produces an external feminisation. 4. In man, cryptorchidism, agenesis of the spermatic tracts, anorchia and hypospady are known as non-hereditary malformations. 5. The teratogenic etiology of some disturbances of the spermatogenesis is discussed.
Keywords: Androgens; Animals, Laboratory; Antimetabolites--side effects; Biology; Clinical Research; Congenital Abnormalities--etiology; Cyproterone Acetate--side effects; Diseases; Endocrine System; Estrogens--side effects; Genitalia; Genitalia, Male; Gonadotropins; Gonadotropins, Chorionic--administraction and dosage; Gonadotropins, Chorionic--therapeutic use; Hormone Antagonists--side effects; Hormones; Metabolic Effects; Neonatal Diseases And Abnormalities; Physiology; Reproduction; Research Methodology; Sperm Maturation Blocking Agents; Spermatogenesis; Testis; Testosterone--side effects; Urogenital Effects; Urogenital System
MeSH terms
Abnormalities, Drug-Induced; Adult; Busulfan; Cryptorchidism; Cyproterone; Female; Genitalia, Male; Humans; Hypospadias; Infant, Newborn; Infertility, Male; Male; Pregnancy; Spermatogenesis
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