Determination of the kappa anti-alpha(1,3) dextran immune response difference by A gene(s) in the VKappa-locus of mice.
J Exp Med, 1979/5/01;149(5):1265-70.
de Preval C, Blomberg B, Cohn M
PMID: 109565
Impact factor: 17.579
Abstract
Mice lacking the V(alpha(1,3) (h gamma1)-gene do not produce a gamma1 anti-alpha(1,3) dextran response. However, on hyperimmunization some strains mount a kappa-anti-alpha(1,3) dextran response, whereas other remain nonresponder. Responsiveness in dominant. The kappa-anti-alpha(1,3) response difference is linked to the Ly-3 locus on chromosone 6 and is likely the result of a structural Vkappa-gene(s). In conjunction with previous work, three Vkappa-allogroups can now be distinguished. At present, this is the only example of an immune responsiveness difference associated with the Vkappa-locus.
MeSH terms
Animals; Antigens; Chromosomes; Crosses, Genetic; Dextrans; Genes, MHC Class II; Genetic Linkage; Immunoglobulin Light Chains; Immunoglobulin kappa-Chains; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C57BL
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