IgA anti-dextran B1355 responses.
J Immunol, 1979/3;122(3):866-70.
PMID: 109506
Impact factor: 5.426
Abstract
Injection of mice bearing the Ig-1a allotype with dextran B1355 results in an IgM antibody response that is generally regarded as thymus independent. Moreover, the antibody is directed to alpha[1,3] determinants on dextran B1355 and shares cross-reacting idiotypic determinants with a lambda 1 IgA (J558) myeloma protein as well as a lambda 1 IgM (MOPC 104E) myeloma protein. In this study, we show that BALB/c (Ig-1a) mice injected with dextran B1355 produced highly significant IgA anti-dextran responses with specificity directed to the alpha[1,3] epitope. Kinetics of the IgA anti-dextran response in BALB/c mice paralleled kinetics of the IgM response. However, the magnitude of the IgA response was markedly T cell dependent and age dependent.
MeSH terms
Aging; Animals; Antibody Formation; Binding, Competitive; Dextrans; Female; Immune Sera; Immunoglobulin A; Immunoglobulin M; Immunoglobulin mu-Chains; Immunologic Memory; Kinetics; Male; Mice; Mice, Inbred BALB C; Mice, Nude; T-Lymphocytes
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