[Causes and risks in a interruption of systemic immunosuppressive therapy following kidney transplantation].
Chir Forum Exp Klin Forsch, 1977/4;:259-63.
Wagner E, Offner G, Wonigeit K, Brölsch C, Coburg AJ, Pichlmayr R
PMID: 109262
Abstract
The immunosuppressive therapy of 22 transplant recipients was temporarily suspended 25 times resulting in rejection reactions in 7 cases with the eventual loss of five transplants. One patient succumbed to fungal infection following the loss of kidney function. No connection between the risk of rejection and the previous number of rejection treatments or the histocompatibility could be established. Acute rejection reactions mostly occurred immediately after the interruption of therapy. There was no increased risk associated with a longer break in treatment. Interruption of therapy during the first period of immunosuppressive treatment, that is approximately 3 months after transplantation, was associated with the lowest risk of rejection. As a result of our experience in 25 cases it appears that the temporary suspension of immunosuppressive therapy is associated with little risk and avoids a drug intoxication as well as reduces the mortality due to infection.
MeSH terms
Azathioprine; Graft Rejection; Histocompatibility; Humans; Immunosuppressive Agents; Infection Control; Infections; Kidney Transplantation; Prednisone; Risk; Time Factors; Transplantation, Homologous
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