Gas chromatographic determination of glibenclamide in plasma.
Clin Chim Acta, 1979/4/16;93(2):195-8.
PMID: 109236
Impact factor: 6.314
Abstract
A gas-chromatographic method for glibenclamide determination in plasma is described. It involves derivatization of the drug with dinitrofluorobenzene and the use of an electron-capture detector. The quantitative evaluation is performed using tolbutamide as internal standard. Characteristics and specificity of the method for the principal metabolite of glibenclamide are examined.
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