Des 4-trans-hydroxy-glibenclamide show hypoglycemic activity?
Arzneimittelforschung, 1979;29(1):162-3.
Balant L, Fabre J, Loutan L, Samimi H
PMID: 109099
Abstract
Different doses of glibenclamide and of 4-transhydroxy-glibenclamide (main metabolite in man) were administered i.p. to rats and blood glucose was measured. The comparison of the doses capable of producing a 30% decrease of the glycemia shows that 4-trans-hydroxy-glibenclamide is about 6.5 times less potent than glibenclamide in our experimental conditions.
MeSH terms
Animals; Blood Glucose; Glyburide; Hydroxylation; Hypoglycemic Agents; Injections, Intraperitoneal; Rats; Time Factors
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