Histaminergic involvement in thyrotropin-releasing hormone stimulation of antral tissue in the rat.
Gastroenterology, 1979/5;76(5 Pt 1):908-12.
Bruce LA, Behsudi FM, Fawcett CP
PMID: 108175
Impact factor: 33.883
Abstract
The mechanism of action of thyrotropin-releasing hormone on antral motility was investigated in vitro. With the recent detection of thyrotropin-releasing hormone in gastrointestinal tissue, the possibility exists that the peptide may play a physiologic role in gastrointestinal motility. Results indicate that the hormone stimulates antral motility through a non-cholinergic excitatory pathway based on the inability of the muscarinic antagonist, atropine, to block the response. A histaminergic pathway is an attractive possibility to explain the excitatory response, because both pyrilamine and cimetidine inhibit the thyrotropin-releasing hormone induced response and the peptide has no further influence on antral motility after the tissue is exposed to a supramaximal concentration of histamine.
MeSH terms
Animals; Atropine; Bethanechol Compounds; Cimetidine; Histamine; In Vitro Techniques; Male; Muscle Contraction; Pyloric Antrum; Pyrilamine; Rats; Thyrotropin-Releasing Hormone
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