[Isolated rat hepatocytes. Simultaneous study of variations in sialic acid content of glycoconjugated membranes and asialotransferrin uptake].
C R Seances Acad Sci D, 1979/2/05;288(5):523-6.
Durand G, Dumont JP, Appel M, Durand D, Davy J, Féger J, Agneray J
PMID: 108021
Abstract
Hepatocytes isolated from streptozotocin treated Rats bind less asialotransferrin than hepatocytes isolated from normal rats. This decrease is parallel with a decrease in the sialic acid content. Insulin therapy restored simultaneously membrane sialic acid content and asialotransferrin binding capacity.
MeSH terms
Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glycoproteins; Insulin; Liver; Male; Membranes; Protein Binding; Rats; Sialic Acids; Transferrin
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