A trial of minocycline given after exposure to prevent gonorrhea.
N Engl J Med, 1979/5/10;300(19):1074-8.
Harrison WO, Hooper RR, Wiesner PJ, Campbell AF, Karney WW, Reynolds GH, Jones OG, Holmes KK
PMID: 107450
Impact factor: 176.079
Abstract
In a prospective evaluation of antibiotic prophylaxis against gonorrhea, 1080 men were given 200 mg of oral minocycline or placebo after sexual intercourse with prostitutes in a Far Eastern port. Later, at sea, gonococcal infection was detected in 57 of 565 men given placebo and 24 of 515 men given minocycline (P less than 0.001). Minocycline prophylaxis completely prevented infection by gonococci susceptible to 0.75 microgram or less of tetracycline per milliliter, reduced the risk of infection or prolonged the incubation period in men exposed to gonococci susceptible to 1.0 to 2.0 micrograms per milliliter, but did not prevent infection or prolong incubation in men exposed to gonococci resistant to 2.0 micrograms. Minocycline did not increase the proportion of asymptomatic infections. Minocycline prophylaxis would probably have limited effectiveness as a public-health measure because of the tendency to select resistant gonococci.
MeSH terms
Administration, Oral; Coitus; Drug Evaluation; Drug Resistance, Microbial; Far East; Gonorrhea; Humans; Male; Minocycline; Naval Medicine; Neisseria gonorrhoeae; Sex Work; Tetracycline; Tetracyclines; Time Factors; United States; Urethritis
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