The use of a hydrophobic matrix for the sustained release of a highly water soluble drug.
Drug Dev Ind Pharm, 2000/1;26(1):79-83.
Martini LG[1], Coles M, Gravell K, Stephenson S, Thomson CM
Affiliations
PMID: 10677813
Impact factor: 3.727
Abstract
An experimental investigation into the use of a hydrophobic matrix to control the release of a highly water soluble drug was undertaken. Matrices consisting of hydrogenated vegetable oil and calcium sulfate with a 4% drug loading showed a sustained-release profile of up to 24 hr. The release mechanism from such matrices seemed to obey both root time kinetics and first-order behavior. Investigations showed that the effect of geometry had a significant effect on the drug release rate.
MeSH terms
Algorithms; Calcium Sulfate; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Excipients; Plant Oils; Solubility; Tablets
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