[Endocrine disorders in children with neurofibromatosis von Recklinghausen (author's transl)].
Monatsschr Kinderheilkd, 1979/3;127(3):135-8.
Andler W, Roosen K, Kohns U, Stolecke H
PMID: 106238
Abstract
Endocrine disturbances have been studied in 4 children with neurofibromatosis von Recklinghausen, aged 5.0-10.5 years. Hypothalamic precocious puberty was seen in three boys; growth hormone deficiency was diagnosed in a girl. After TRH stimulation one boy and the girl showed a diminished TSH-response. Another boy showed a relatively high basal level of TSH and an elevated TSH-response to TRH. All children were euthyroid. Two boys had a hyperprolactinemia even under basal conditions; the one with elevated TSH-response showed an excessive response of prolactin as well. In all our patients a suprasellar tumor caused the endocrine disorders described.
MeSH terms
Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Endocrine System Diseases; Female; Growth Hormone; Humans; Male; Neurofibromatosis 1; Prolactin; Puberty, Precocious
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